An extensive investigation based on declassified government documents and previously suppressed scientific research has uncovered compelling evidence that U.S. biological weapons programs contributed to the emergence of Lyme disease, which now affects hundreds of thousands of Americans annually. Declassified documents and testimony from a CIA operative describe the 1962 deployment of infected ticks against Cuban sugarcane workers as part of Operation Mongoose, the Kennedy administration’s effort to destabilize Fidel Castro’s regime.