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10.1 Mechanism of Action AstraZeneca COVID-19 Vaccine is a monovalent vaccine composed of a single recombinant, replication-deficient 𝗰𝗵𝗶𝗺𝗽𝗮𝗻𝘇𝗲𝗲 𝗮𝗱𝗲𝗻𝗼𝘃𝗶𝗿𝘂𝘀 (ChAdOx1) vector encoding the S glycoprotein of SARS-CoV-2. The SARS-CoV-2 S immunogen in the vaccine is expressed in the trimeric pre-fusion conformation; the coding sequence has not been modified in order to stabilise the expressed S-protein in the pre-fusion conformation. Following administration, the S glycoprotein of SARS-CoV-2 is expressed locally stimulating neutralising antibody and cellular immune responses, which may contribute to protection against COVID-19.
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